Optimizing Outcome Assessment in Multicenter TBI Trials: Perspectives From TRACK-TBI and the TBI Endpoints Development Initiative
نویسندگان
چکیده
منابع مشابه
Respond to Neuropsychological Outcome in Chronic Tbi Participants
Objectives: Traumatic brain injury (TBI) involves axonal injury and accumulation of pathological protein aggregates including amyloid-b (Ab) and hyperphosphorylated tau (p-tau). Biomarker analysis of tau and Ab concentrations in cerebrospinal fluid (CSF) may be an objective marker of cognitive status after TBI. The goal of the current study was to analyze tau and Ab 40–42 in a cohort of militar...
متن کاملPathophysiology, classification and clinical management of TBI
Traumatic brain injury (TBI; see Box 1 for a glossary of terms) is a leading cause of death and disability worldwide, particularly for persons under 45 years of age (Hyder et al., 2007; Mass et al., 2008). In the United States, the overall incidence of TBI is estimated to be 538 per 100,000 individuals, which represents at least 1.7 million new cases per year since 2003 (Gerberding and Binder, ...
متن کاملStatistical Issues in TBI Clinical Studies
The identification and longitudinal assessment of traumatic brain injury presents several challenges. Because these injuries can have subtle effects, efforts to find quantitative physiological measures that can be used to characterize traumatic brain injury are receiving increased attention. The results of this research must be considered with care. Six reasons for cautious assessment are outli...
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ژورنال
عنوان ژورنال: Journal of Head Trauma Rehabilitation
سال: 2018
ISSN: 0885-9701
DOI: 10.1097/htr.0000000000000367